Natural Tips Against Covid-19

on December 13, 2020

Natural Tips Against Covid-19

Evidence-based recommendations to reduce severity, duration of illness and support recovery. 

Found in turmeric, decreases inflammation and a preprint suggests curcumin targets the SARS-CoV-2 main protease to reduce viral replication.


Vitamin C: Boosts cellular defense and repair mechanisms from viral damage.

Quercetin: Promotes viral inactivation and inhibits replication.

Quercetin, Vitamin C

Palmitoylethanolamide (PEA)

Reduces inflammation and, based on a preprint, targets the SARS-CoV-2 main protease (Mpro) to reduce viral replication. Also shown to prevent influenza in healthcare workers.


A naturally occurring anti-inflammatory found in soy. 5 double blind placebo-controlled trials showed it helped against the inflammatory process of acute respiratory disease due to influenza. Likely works by inhibiting the potentially fatal cytokine storm.


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Kinker B, Comstock AT, Sajjan US. Quercetin: a promising treatment for the common cold. J Anc Dis Prev Rem. 2014;2:2:1000111. doi:10.4172/2329-8731.1000111

Somerville VS, Braakhuis AJ, Hopkins WG. Effect of flavonoids on upper respiratory tract infections and immune function: a systematic review and meta-analysis. Adv Nutr. 2016;7(3):488-497. doi:10.3945/an.115.010538

Qiu X, Kroeker A, He S, et al. Prophylactic efficacy of quercetin 3-?-O-D-glucoside against Ebola virus infection. Antimicrob Agents Chemother. 2016;60(9):5182-5188. doi:10.1128/AAC.00307-16

Wong G, He S, Siragam V, et al. Antiviral activity of quercetin-3-?-O-D-glucoside against Zika virus infection. Virol Sin. 2017;32(6):545-547. doi:10.1007/s12250-017-4057-9

Yi YS. Regulatory roles of flavonoids on inflammasome activation during inflammatory responses. Mol Nutr Food Res. 2018;62(13):e1800147. doi:10.1002/mnfr.201800147

Sun Y, Liu W, Zhang H, et al. Curcumin prevents osteoarthritis by inhibiting the activation of inflammasome NLRP3. J Interferon Cytokine Res. 2017;37(10):449-455. doi:10.1089/jir.2017.0069

Andres S, Pevny S, Ziegenhagen R, et al. Safety aspects of the use of quercetin as a dietary supplement. Mol Nutr Food Res. 2018;62(1). doi:10.1002/mnfr.201700447

Oarowski M, Mikoajczak P, Kujawski R, et al. Pharmacological effect of quercetin in hypertension and its potential application in pregnancy-induced hypertension: review of in vitro, in vivo, and clinical studies. Evid Based Complement Alternat Med. 2018;2018:7421489. doi:10.1155/2018/7421489

Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S. Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study. Preprints. Published online March 13, 2020. doi:10.20944/preprints202003.0226.v1

Yin H, Guo Q, Li X, et al. Curcumin suppresses IL-1? secretion and prevents inflammation through inhibition of the NLRP3 inflammasome. J Immunol. 2018;200(8):2835-2846. doi:10.4049/jimmunol.1701495

Gong Z, Zhao S, Zhou J, et al. Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1? production. Mol Immunol. 2018;104:11-19. doi:10.1016/j.molimm.2018.09.004

Zhao J, Wang J, Zhou M, Li M, Li M, Tan H. Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome. Int Immunopharmacol. 2019;69:213-216. doi:10.1016/j.intimp.2019.01.046

Kunnumakkara AB, Bordoloi D, Padmavathi G, et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325-1348. doi:10.1111/bph.13621

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Ng QX, Koh SSH, Chan HW, Ho CYX. Clinical use of curcumin in depression: a meta-analysis. J Am Med Dir Assoc. 2017;18(6):503-508. doi:10.1016/j.jamda.2016.12.071

Ng QX, Soh AYS, Loke W, Venkatanarayanan N, Lim DY, Yeo WS. A meta-analysis of the clinical use of curcumin for irritable bowel syndrome (IBS). J Clin Med. 2018;7(10):E298. doi:10.3390/jcm7100298

Bahramsoltani R, Rahimi R, Farzaei MH. Pharmacokinetic interactions of curcuminoids with conventional drugs: a review. J Ethnopharmacol. 2017;209:1-12. doi:10.1016/j.jep.2017.07.022

Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM. Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial. BMC Complement Altern Med. 2011;11:15. doi:10.1186/1472-6882-11-15

Lee HE, Yang G, Park YB, et al. Epigallocatechin-3-gallate prevents acute gout by suppressing NLRP3 inflammasome activation and mitochondrial DNA synthesis. Molecules. 2019;24(11):E2138. doi:10.3390/molecules24112138

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Chow HH, Cai Y, Hakim IA, et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. 2003;9(9):3312-3319.

Isomura T, Suzuki S, Origasa H, et al. Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials [published correction appears in Eur J Clin Nutr. 2016;70(11):1221-1229]. Eur J Clin Nutr. 2016;70(11):1340. doi:10.1038/ejcn.2016.78

Sarma DN, Barrett ML, Chavez ML, et al. Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf. 2008;31(6):469-484. doi:10.2165/00002018-200831060-00003

Oketch-Rabah HA, Roe AL, Rider CV, et al. United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts. Toxicol Rep. 2020;7:386-402. doi:10.1016/j.toxrep.2020.02.008

Younes M, Aggett P, Aguilar F, et al. Scientific opinion on the safety of green tea catechins. EFSA J. 2018;16(4):e05239. doi:10.2903/j.efsa.2018.5239

McCarty MF, DiNicolantonio JJ. Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus. Prog Cardiovasc Dis. Published online February 12, 2020. doi:10.1016/j.pcad.2020.02.007



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