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Natural Tips Against Covid-19

on December 13, 2020

Natural Tips Against Covid-19

Evidence-based recommendations to reduce severity, duration of illness and support recovery. 

Found in turmeric, decreases inflammation and a preprint suggests curcumin targets the SARS-CoV-2 main protease to reduce viral replication.

Curcumin

Vitamin C: Boosts cellular defense and repair mechanisms from viral damage.

Quercetin: Promotes viral inactivation and inhibits replication.

Quercetin, Vitamin C

Palmitoylethanolamide (PEA)

Reduces inflammation and, based on a preprint, targets the SARS-CoV-2 main protease (Mpro) to reduce viral replication. Also shown to prevent influenza in healthcare workers.

EGCG

A naturally occurring anti-inflammatory found in soy. 5 double blind placebo-controlled trials showed it helped against the inflammatory process of acute respiratory disease due to influenza. Likely works by inhibiting the potentially fatal cytokine storm.

References

Wu W, Li R, Li X, et al. Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses. 2015;8(1):E6. doi:10.3390/v8010006

Kinker B, Comstock AT, Sajjan US. Quercetin: a promising treatment for the common cold. J Anc Dis Prev Rem. 2014;2:2:1000111. doi:10.4172/2329-8731.1000111

Somerville VS, Braakhuis AJ, Hopkins WG. Effect of flavonoids on upper respiratory tract infections and immune function: a systematic review and meta-analysis. Adv Nutr. 2016;7(3):488-497. doi:10.3945/an.115.010538

Qiu X, Kroeker A, He S, et al. Prophylactic efficacy of quercetin 3-?-O-D-glucoside against Ebola virus infection. Antimicrob Agents Chemother. 2016;60(9):5182-5188. doi:10.1128/AAC.00307-16

Wong G, He S, Siragam V, et al. Antiviral activity of quercetin-3-?-O-D-glucoside against Zika virus infection. Virol Sin. 2017;32(6):545-547. doi:10.1007/s12250-017-4057-9

Yi YS. Regulatory roles of flavonoids on inflammasome activation during inflammatory responses. Mol Nutr Food Res. 2018;62(13):e1800147. doi:10.1002/mnfr.201800147

Sun Y, Liu W, Zhang H, et al. Curcumin prevents osteoarthritis by inhibiting the activation of inflammasome NLRP3. J Interferon Cytokine Res. 2017;37(10):449-455. doi:10.1089/jir.2017.0069

Andres S, Pevny S, Ziegenhagen R, et al. Safety aspects of the use of quercetin as a dietary supplement. Mol Nutr Food Res. 2018;62(1). doi:10.1002/mnfr.201700447

Oarowski M, Mikoajczak P, Kujawski R, et al. Pharmacological effect of quercetin in hypertension and its potential application in pregnancy-induced hypertension: review of in vitro, in vivo, and clinical studies. Evid Based Complement Alternat Med. 2018;2018:7421489. doi:10.1155/2018/7421489

Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S. Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study. Preprints. Published online March 13, 2020. doi:10.20944/preprints202003.0226.v1

Yin H, Guo Q, Li X, et al. Curcumin suppresses IL-1? secretion and prevents inflammation through inhibition of the NLRP3 inflammasome. J Immunol. 2018;200(8):2835-2846. doi:10.4049/jimmunol.1701495

Gong Z, Zhao S, Zhou J, et al. Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1? production. Mol Immunol. 2018;104:11-19. doi:10.1016/j.molimm.2018.09.004

Zhao J, Wang J, Zhou M, Li M, Li M, Tan H. Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome. Int Immunopharmacol. 2019;69:213-216. doi:10.1016/j.intimp.2019.01.046

Kunnumakkara AB, Bordoloi D, Padmavathi G, et al. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325-1348. doi:10.1111/bph.13621

Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003;9(1):161-168. doi:10.1089/107555303321223035

Ng QX, Koh SSH, Chan HW, Ho CYX. Clinical use of curcumin in depression: a meta-analysis. J Am Med Dir Assoc. 2017;18(6):503-508. doi:10.1016/j.jamda.2016.12.071

Ng QX, Soh AYS, Loke W, Venkatanarayanan N, Lim DY, Yeo WS. A meta-analysis of the clinical use of curcumin for irritable bowel syndrome (IBS). J Clin Med. 2018;7(10):E298. doi:10.3390/jcm7100298

Bahramsoltani R, Rahimi R, Farzaei MH. Pharmacokinetic interactions of curcuminoids with conventional drugs: a review. J Ethnopharmacol. 2017;209:1-12. doi:10.1016/j.jep.2017.07.022

Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM. Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial. BMC Complement Altern Med. 2011;11:15. doi:10.1186/1472-6882-11-15

Lee HE, Yang G, Park YB, et al. Epigallocatechin-3-gallate prevents acute gout by suppressing NLRP3 inflammasome activation and mitochondrial DNA synthesis. Molecules. 2019;24(11):E2138. doi:10.3390/molecules24112138

Mereles D, Hunstein W. Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises? Int J Mol Sci. 2011;12(9):5592-5603. doi:10.3390/ijms12095592

Chow HH, Cai Y, Hakim IA, et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. 2003;9(9):3312-3319.

Isomura T, Suzuki S, Origasa H, et al. Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials [published correction appears in Eur J Clin Nutr. 2016;70(11):1221-1229]. Eur J Clin Nutr. 2016;70(11):1340. doi:10.1038/ejcn.2016.78

Sarma DN, Barrett ML, Chavez ML, et al. Safety of green tea extracts: a systematic review by the US Pharmacopeia. Drug Saf. 2008;31(6):469-484. doi:10.2165/00002018-200831060-00003

Oketch-Rabah HA, Roe AL, Rider CV, et al. United States Pharmacopeia (USP) comprehensive review of the hepatotoxicity of green tea extracts. Toxicol Rep. 2020;7:386-402. doi:10.1016/j.toxrep.2020.02.008

Younes M, Aggett P, Aguilar F, et al. Scientific opinion on the safety of green tea catechins. EFSA J. 2018;16(4):e05239. doi:10.2903/j.efsa.2018.5239

McCarty MF, DiNicolantonio JJ. Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus. Prog Cardiovasc Dis. Published online February 12, 2020. doi:10.1016/j.pcad.2020.02.007

 

 

The statements made on this website have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results vary and are not guaranteed.

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